Probing the effects of the well-mixed assumption on viral infection dynamics

DOI10.1016/J.JTBI.2006.03.014zbMATH Open1447.92397arXivq-bio/0505043OpenAlexW2060982649WikidataQ47852502 ScholiaQ47852502MaRDI QIDQ2201897FDOQ2201897

Catherine A. A. Beauchemin

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Viral kinetics have been extensively studied in the past through the use of spatially well-mixed ordinary differential equations describing the time evolution of the diseased state. However, emerging spatial structures such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. In a previous publication (Beauchemin et al., 2005), a simple 2-D cellular automaton model was introduced and shown to be accurate enough to model an uncomplicated infection with influenza A. Here, this model is used to investigate the effects of relaxing the well-mixed assumption. Particularly, the effects of the initial distribution of infected cells, the regeneration rule for dead epithelial cells, and the proliferation rule for immune cells are explored and shown to have an important impact on the development and outcome of the viral infection in our model.

Full work available at URL: https://arxiv.org/abs/q-bio/0505043

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zbMATH Keywords

agent-based modelsspatial heterogeneitycellular automatonindividual-based modelsmathematical modellingviral infection dynamicswell-mixed assumption

Mathematics Subject Classification ID

Epidemiology (92D30) Cellular automata (computational aspects) (68Q80)

Cites Work

• The importance of being discrete (and spatial)
• A simple cellular automaton model for influenza A viral infections
• Spatial models of virus-immune dynamics
• A cellular automata model of tumor-immune system interactions
• Identifying control mechanisms of granuloma formation during \textit{M. tuberculosis} infection using an agent-based model
• Spatial heterogeneity and the persistence of infectious diseases
• Modeling complexity in biology

Cited In (13)

• Varying inoculum dose to assess the roles of the immune response and target cell depletion by the pathogen in control of acute viral infections
• Parameter estimation and sensitivity analysis in an agent-based model of \textit{Leishmania major} infection
• A multiscale multicellular spatiotemporal model of local influenza infection and immune response
• A hybrid stochastic-deterministic computational model accurately describes spatial dynamics and virus diffusion in HIV-1 growth competition assay
• A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention
• Towards multiscale modeling of influenza infection
• Predicting pathogen-specific CD8 T cell immune responses from a modeling approach
• Modeling HIV-1 dynamics and fitness in cell culture across scales
• Choice of spatial discretisation influences the progression of viral infection within multicellular tissues
• Mathematical modeling of viral infection dynamics in spherical organs
• ON EXPLORING EFFECTS OF MOLECULAR NOISE IN A SIMPLE VIRAL INFECTION MODEL
• The impact of cell regeneration on the dynamics of viral coinfection
• Reaction-diffusion equations in immunology

Uses Software

• MASyV

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