A simple cellular automaton model for influenza A viral infections

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Publication:776479

DOI10.1016/J.JTBI.2004.08.001zbMATH Open1442.92153arXivq-bio/0402012OpenAlexW1965004987WikidataQ47866416 ScholiaQ47866416MaRDI QIDQ776479FDOQ776479


Authors: John Samuel, J. A. Tuszyński, Catherine A. A. Beauchemin Edit this on Wikidata


Publication date: 9 July 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Viral kinetics have been extensively studied in the past through the use of spatially homogeneous ordinary differential equations describing the time evolution of the diseased state. However, spatial characteristics such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. In order to investigate the influence of spatial heterogeneities on viral spread, a simple 2-D cellular automaton (CA) model of a viral infection has been developed. In this initial phase of the investigation, the CA model is validated against clinical immunological data for uncomplicated influenza A infections. Our results will be shown and discussed.


Full work available at URL: https://arxiv.org/abs/q-bio/0402012




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