Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps

DOI10.1016/J.JTBI.2006.11.016MaRDI QIDQ2210014zbMATH OpenOpenAlexWikidataFDO

Authors Emi Shudo, Jin Yang, Akihiko Yoshimura, Yoh Iwasa

Publication date 5 November 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.11.016

zbMATH Keywords

dimerizationJAK/STAT pathwaynegative feedbackrobust system

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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Cites work

• Dynamic optimization of host defense, immune memory, and post-infection pathogen levels in mammals
• Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger
• Optimal phosphorylation step number of intracellular signal-transduction pathway
• Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories

Cited in

(7)

• Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2
• Transient pulse formation in jasmonate signaling pathway
• Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback
• REFINEMENT: a search framework for the identification of interferon-responsive elements in DNA sequences -- a case study with ISRE and GAS
• Model-based selection of the robust JAK-STAT activation mechanism
• MODELING THE NONLINEAR DYNAMICS OF CELLULAR SIGNAL TRANSDUCTION
• Negative feedback contributes to the stochastic expression of the interferon-\(\beta\) gene in virus-triggered type I interferon signaling pathways

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