Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories

DOI10.1016/S0022-5193(03)00011-0zbMATH Open1464.92110arXivphysics/0206075WikidataQ46024499 ScholiaQ46024499MaRDI QIDQ2177166FDOQ2177166

Herbert M. Sauro, Brian P. Ingalls

Publication date: 6 May 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given, and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction.

Full work available at URL: https://arxiv.org/abs/physics/0206075

zbMATH Keywords

sensitivity analysisnetworkssystems biologytransient dynamicsmetabolic control analysis

Mathematics Subject Classification ID

Systems biology, networks (92C42) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cites Work

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