Use of implicit methods from general sensitivity theory to develop a systematic appoach to metabolic control. I: Unbranched pathways

DOI10.1016/0025-5564(89)90067-9MaRDI QIDQ1123836zbMATH OpenOpenAlexWikidataFDO

Authors Marta Cascante, Rafael Franco, Enric I. Canela

Publication date 1989

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(89)90067-9

zbMATH Keywords

concentration connectivityconcentration control coefficientsconcentration summationenzyme concentrationenzyme elasticities matrixflux connectivityflux summation theoremmatrix algebrametabolic control theorysensitivity theorysequential reactionssteady stateunbranched chain structures of metabolic pathways

Mathematics Subject Classification ID

Matrix equations and identities (15A24) Chemical kinetics in thermodynamics and heat transfer (80A30) Physiological, cellular and medical topics (92Cxx) Sensitivity (robustness) (93B35)

Review text

On the basis of general sensitivity theory (which studies the effects of parameter variations on the behaviour of dynamic systems) a matrix algebra is developed and used for unbranched chain structures of metabolic pathways in the steady state. For such sequential reactions (in steady state) the enzyme elasticities matrix is derived as a product of the elasticities matrix and the matrix of flux and concentration control coefficients. In the particular case of all the velocities of the system being homogeneous with respect to the system enzymes, i.e. each reaction is a linear function of the corresponding enzyme concentration, the enzyme elasticities matrix is the identity matrix and the resulting matrix equation relates global (systemic) properties (flux and concentration control coefficients) with local properties (elasticity matrix) in a simple manner insofar as each matrix is the inverse of the other. By this relation it is also shown that the theorems of the metabolic control theory (the so-called flux summation theorem, concentration connectivity th., concentration summation th., and flux connectivity th.) may not be considered as fundamental equations but rather as consequences of the theory of sensitivity which provides in this sense a generalization of the metabolic control theory.

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Cites work

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• Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: Model definition and nomenclature
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• Synergism analysis of biochemical systems. I: Conceptual framework
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• Sensitivity and control analysis of periodically forced reaction networks using the Green's function method
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• Metabolic control analysis of trio enzymes system
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• How do inhibitors and modifiers of individual enzymes affect steady-state fluxes and concentrations in metabolic systems?
• Sign Pattern Analysis of Control Coefficients of Metabolic Pathways
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• scientific article; zbMATH DE number 880333 (Why is no real title available?)
• Dynamics of an open metabolic cycle at the surface of a charged membrane. I: A simple general model

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