Assessing the origin and velocity of Ca^2+ waves in three-dimensional tissue: insights from a mathematical model and confocal imaging in mouse pancreas tissue slices

DOI10.1016/J.CNSNS.2020.105495MaRDI QIDQ2212018zbMATH OpenOpenAlexFDO

Authors Marko Šterk, Jurij Dolenšek, Lidija Križančić Bombek, Rene Markovič, Darko Zakelšek, Matjaž Perc, Viljem Pohorec, Andraž Stožer, Marko Gosak

Publication date 17 November 2020

Published in Communications in Nonlinear Science and Numerical Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.cnsns.2020.105495

zbMATH Keywords

calcium wave velocityconfocal imagingmulticellular modelpancreatic islets

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37) Medical applications (general) (92C50) Biomedical imaging and signal processing (92C55)

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Cites work

• Computational modelling of nonlinear calcium waves
• Integrated multiscale mathematical modeling of insulin secretion reveals the role of islet network integrity for proper oscillatory glucose-dose response
• Key aspects for effective mathematical modelling of fractional-diffusion in cardiac electrophysiology: a quantitative study
• Modeling of spiking-bursting neural behavior using two-dimensional map
• On the coherent behavior of pancreatic beta cell clusters
• The dynamics of ensemble of neuron-like elements with excitatory couplings
• The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue
• Variety of spatio-temporal regimes in a 2D lattice of coupled bistable FitzHugh-Nagumo oscillators. Formation mechanisms of spiral and double-well chimeras
• Wave speeds of density dependent Nagumo diffusion equations, inspired by oscillating gap-junction conductance in the islets of Langerhans

Cited in

(1)

• Estimation of the traveling wave speed in pancreatic islets using high period periodic orbits

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