Modeling homeoprotein intercellular transfer unveils a parsimonious mechanism for gradient and boundary formation in early brain development

DOI10.1016/J.JTBI.2007.07.026MaRDI QIDQ2216342zbMATH OpenOpenAlexWikidataFDO

Authors D. Holcman, V. Kasatkin, A. Prochiantz

Publication date 15 December 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2007.07.026

zbMATH Keywords

reaction-diffusion equationdevelopmentnoise analysismorphogenetic gradientsboundary formationhomeoprotein intercellular transfer

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Developmental biology, pattern formation (92C15) Cell biology (92C37)

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(6)

• Mixed analytical-stochastic simulation method for the recovery of a Brownian gradient source from probability fluxes to small windows
• Cortical geometry may influence placement of interface between Par protein domains in early \textit{Caenorhabditis elegans} embryos
• MECP2: a multifunctional protein supporting brain complexity
• Stochastic modeling of gene activation and applications to cell regulation
• Morphogenesis by coupled regulatory networks: reliable control of positional information and proportion regulation
• Morphogenetic gradients and the stability of boundaries between neighboring morphogenetic regions

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