Stochastic modeling of gene activation and applications to cell regulation

DOI10.1016/J.JTBI.2010.11.032zbMATH Open1405.92178arXiv1010.3001OpenAlexW1991779933WikidataQ52712750 ScholiaQ52712750MaRDI QIDQ1670565FDOQ1670565

G. Malherbe, D. Holcman

Publication date: 6 September 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Transcription factors (TFs) are key regulators of gene expression. Based on the classical scenario in which the TF search process switches between one-dimensional motion along the DNA molecule and free Brownian motion in the nucleus, we study the arrival time of several TFs to multiple binding sites and derive, in the presence of competitive binding ligands, the probability that several target sites are bound. We then apply our results to the hunchback regulation by bicoid in the fly embryo and we propose a general mechanism that allows cells to read a morphogenetic gradient and specialize according to their position in the embryo.

Full work available at URL: https://arxiv.org/abs/1010.3001

zbMATH Keywords

cell differentiationmorphogenetic gradientgene activationgenetic switchstochastic binding

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Ecology (92D40)

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Cited In (5)

• Polymer physics of nuclear organization and function
• Stochastic modelling of gene regulatory networks
• A Stochastic Model of the Production of Multiple Proteins in Cells
• Modelling Nonstationary Gene Regulatory Processes
• Random dynamics of gene transcription activation in single cells

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