Random dynamics of gene transcription activation in single cells

DOI10.1016/J.JDE.2009.06.006MaRDI QIDQ842896zbMATH OpenOpenAlexFDO

Authors P. Felmer, Alexander Quaas, Moxun Tang, Jianshe Yu

Publication date 28 September 2009

Published in Journal of Differential Equations (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jde.2009.06.006

zbMATH Keywords

differentiabilitymaster equationmaster operatormollification propertyP-type functionssingle cell resolution

Mathematics Subject Classification ID

Ordinary differential equations and systems with randomness (34F05) Markov chains (discrete-time Markov processes on discrete state spaces) (60J10) Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Cell biology (92C37) Biochemistry, molecular biology (92C40)

Review text

The authors continue to study the qualitative behavior of the master equation for the probabilities \(P_{n,x}(t)\) that a biologically relevant cell system is at the state \(x\) the \(n\)-th time at time \(t\) (quantifying the timing and strength of gene transcription by \(P\) with \(3\) functional states \(x\)). This system describes the gene transcription activity at single cell resolution. The related random transition model was originally suggested by \textit{M. Tang} [The mean and noise of stochastic gene transcription. J. Theor. Biol. 253, 271--280 (2008)]. For their analysis, the study of the properties of the related master operator \(L\) that transforms the probabilities \(P_{n,x}(t)\) into \(P_{n+1,x}(t)\) (e.g., its mollifying property) turns out to be crucial.

Recommendations

• Transcriptional stochasticity in gene expression
• The dynamics of gene transcription in random environments
• Stochastic models of regulation of transcription in biological cells
• Stochastic regulation of gene expression
• Stochastic gene expression
• Transcription, intercellular variability and correlated random walk
• Distribution profiles and their dynamic transition in stochastic gene transcription
• Stochastic modeling of gene activation and applications to cell regulation
• Gene expression dynamics in randomly varying environments
• Nonlinear dynamics and noise actuated by the cycle of gene inactivation in stochastic transcription

Cites work

• Applied Semi-Markov Processes
• scientific article; zbMATH DE number 3374743 (Why is no real title available?)
• The mean and noise of stochastic gene transcription
• The mean frequency of transcriptional bursting and its variation in single cells

Cited in

(6)

• The mean and noise of stochastic gene transcription with cell division
• Fluctuations of mRNA distributions in multiple pathway activated transcription
• The mean and noise of protein numbers in stochastic gene expression
• Temporal profile of gene transcription noise modulated by cross-talking signal transduction pathways
• MONOTONIC DYNAMICS OF MRNA DEGRADATION BY TWO PATHWAYS
• Modulation of gene transcription noise by competing transcription factors

This page was built for publication: Random dynamics of gene transcription activation in single cells

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q842896)