Targeting cellular DNA damage responses in cancer: an in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR-inhibiting drugs

DOI10.1007/S11538-021-00935-YzbMATH Open1471.92154OpenAlexW3197341712WikidataQ113900130 ScholiaQ113900130MaRDI QIDQ2230682FDOQ2230682

Authors: Yanyan Li 

Publication date: 28 September 2021

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-021-00935-y

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zbMATH Keywords

agent-based modelmathematical oncologyAZD6738DNA damage response inhibition

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10) Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model
• A model for restriction point control of the mammalian cell cycle
• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies
• What does not kill a tumour may make it stronger: \textit{in silico} insights into chemotherapeutic drug resistance
• A model for spheroid versus monolayer response of SK-N-SH neuroblastoma cells to treatment with 15-deoxy-\(PGJ_2\)

Cited In (2)

• Characterising cancer cell responses to cyclic hypoxia using mathematical modelling
• Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

Uses Software

• Chaste
• Matlab
• ParaView
• PhysiCell
• CompuCell3D

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