Targeting cellular DNA damage responses in cancer: an in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR-inhibiting drugs

DOI10.1007/S11538-021-00935-YMaRDI QIDQ2230682zbMATHOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 28 September 2021

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-021-00935-y

zbMATH Keywords

agent-based modelmathematical oncologyAZD6738DNA damage response inhibition

Mathematics Subject Classification ID

Medical applications (general) (92C50) Genetics and epigenetics (92D10) Cell biology (92C37)

Recommendations

• Computational modeling of tumor response to vascular-targeting therapies. I: Validation
• Identifying therapeutic targets in a combined EGFR-TGF\(\beta\)R signalling cascade using a multiscale agent-based cancer model
• A model for spheroid versus monolayer response of SK-N-SH neuroblastoma cells to treatment with 15-deoxy-\(PGJ_2\)
• Interpreting stochastic agent-based models of cell death
• Compartmental modelling of the uptake kinetics of the anti‐cancer agent topotecan in human breast cancer cells

Cites work

• scientific article; zbMATH DE number 43417 (Why is no real title available?)
• A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells
• A model for restriction point control of the mammalian cell cycle
• A model for spheroid versus monolayer response of SK-N-SH neuroblastoma cells to treatment with 15-deoxy-\(PGJ_2\)
• Modeling the spatial distribution of chronic tumor hypoxia: implications for experimental and clinical studies
• Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model
• What does not kill a tumour may make it stronger: \textit{in silico} insights into chemotherapeutic drug resistance

Cited in

(2)

• Characterising cancer cell responses to cyclic hypoxia using mathematical modelling
• Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

Describes a project that uses

Uses Software

• Chaste
• Matlab
• ParaView
• PhysiCell
• CompuCell3D

This page was built for publication: Targeting cellular DNA damage responses in cancer: an in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR-inhibiting drugs

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2230682)