Treatment-induced shrinking of tumour aggregates: a nonlinear volume-filling chemotactic approach

DOI10.1007/S00285-021-01642-XMaRDI QIDQ2232133zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 4 October 2021

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2007.12454

zbMATH Keywords

chemotaxisglioblastomastability analysisvolume-filling approach

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) Pattern formations in context of PDEs (35B36) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Interacting particle systems in time-dependent statistical mechanics (82C22) General biology and biomathematics (92B05) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37) Population dynamics (general) (92D25)

Abstract: Motivated by experimental observations in 3D/organoid cultures derived from glioblastoma, we develop a mathematical model where tumour aggregate formation is obtained as the result of nutrient-limited cell proliferation coupled with chemotaxis-based cell movement. The introduction of a chemotherapeutic treatment induces mechanical changes at the cell level, with cells undergoing a transition from rigid bodies to semi-elastic entities. We analyse the influence of these individual mechanical changes on the properties of the aggregates obtained at the population level by introducing a nonlinear volume-filling chemotactic system of partial differential equations. The elastic properties of the cells are taken into account through the so-called squeezing probability, which allows us to change the packing capacity of the aggregates, depending on the concentration of the treatment in the extracellular microenvironment. We explore two scenarios for the effect of the treatment: firstly, the treatment acts only on the mechanical properties of the cells and, secondly, we assume it also prevents cell proliferation. A linear stability analysis enables us to study the ability of the system to create patterns. We provide numerical simulations in 1D and 2D that illustrate the shrinking of the aggregates due to the presence of the treatment.

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Cited in

(2)

• From a nonlinear kinetic equation to a volume-exclusion chemotaxis model via asymptotic preserving methods
• Positive and negative role of random perturbations in the dynamics of a tumor-immune system with treatment

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