Analysis and simulations on a model for the evolution of tumors under the influence of nutrient and drug application

DOI10.1137/17M1116891MaRDI QIDQ4606691zbMATH OpenWikidataFDO

Authors Konstantina Trivisa, Franziska Weber

Publication date 9 March 2018

Published in SIAM Journal on Numerical Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1602.06476

zbMATH Keywords

cancer progressionexistence of solutionsfinite difference schemesmultiphase flowtumor growth models

Mathematics Subject Classification ID

Navier-Stokes equations (35Q30) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Existence, uniqueness, and regularity theory for compressible fluids and gas dynamics (76N10) Cell movement (chemotaxis, etc.) (92C17)

Abstract: We investigate the evolution of tumor growth relying on a nonlinear model of partial differential equations which incorporates mechanical laws for tissue compression combined with rules for nutrients availability and drug application. Rigorous analysis and simulations are presented which show the role of nutrient and drug application in the progression of tumors. We construct an explicit convergent numerical scheme to approximate solutions of the nonlinear system of partial differential equations. Extensive numerical tests show that solutions exhibit a necrotic core when the nutrient level falls below a critical level in accordance with medical observations. The same numerical experiment is performed in the case of drug application for the purpose of comparison. Depending on the balance between nutrient and drug both shrinkage and growth of tumors can occur. The role of inhomogeneous boundary conditions, vascularization and anisotropies in the development of tumor shape irregularities are discussed.

Recommendations

• On a nonlinear model for tumour growth with drug application
• Vascular tumor growth and treatment: Consequences of polyclonality, competition and dynamic vascular support
• On the vanishing viscosity approximation of a nonlinear model for tumor growth
• Nonlinear analysis of a model of vascular tumour growth and treatment
• scientific article; zbMATH DE number 1531850

Cites work

• A convergent explicit finite difference scheme for a mechanical model for tumor growth
• A Hele-Shaw problem for tumor growth
• A hierarchy of cancer models and their mathematical challenges
• A multiscale approach to the migration of cancer stem cells: mathematical modelling and simulations
• Analytic semigroups and optimal regularity in parabolic problems
• scientific article; zbMATH DE number 2134001 (Why is no real title available?)
• scientific article; zbMATH DE number 1005391 (Why is no real title available?)
• scientific article; zbMATH DE number 807857 (Why is no real title available?)
• scientific article; zbMATH DE number 914383 (Why is no real title available?)
• scientific article; zbMATH DE number 928933 (Why is no real title available?)
• scientific article; zbMATH DE number 3294409 (Why is no real title available?)
• Hypoxia inducible factors-mediated inhibition of cancer by GM-CSF: a mathematical model
• Individual-based and continuum models of growing cell populations: a comparison
• Models for the Growth of a Solid Tumor by Diffusion
• Numerical approximation of hyperbolic systems of conservation laws
• On a chemotaxis model with saturated chemotactic flux
• On a nonlinear model for tumour growth with drug application
• Ordinary differential equations, transport theory and Sobolev spaces
• Selected topics in cancer modeling. Genesis, evolution, immune competition, and therapy
• Traveling wave solution of the Hele-Shaw model of tumor growth with nutrient

Cited in

(10)

• Vascular tumor growth and treatment: Consequences of polyclonality, competition and dynamic vascular support
• A mathematical model of tumor hypoxia targeting in cancer treatment and its numerical simulation
• Modeling of tumor growth incorporating the effects of necrosis and the effect of Bevacizumab
• The model of nutrients influence on the tumor growth
• Treatment-induced shrinking of tumour aggregates: a nonlinear volume-filling chemotactic approach
• Analysis and simulation of a model for intracellular drug accumulation in tumors
• A DISCRETE SIMULATION OF TUMOR GROWTH CONCERNING NUTRIENT INFLUENCE
• NUMERICAL SOLUTION OF A MODEL FOR BRAIN CANCER PROGRESSION AFTER THERAPY
• On a nonlinear model for tumour growth with drug application
• On a nonlinear diffussive model for the evolution of cells within a moving domain

This page was built for publication: Analysis and simulations on a model for the evolution of tumors under the influence of nutrient and drug application

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4606691)