Theoretical modeling of long-time drug release from nitrosalicyl-imine-chitosan hydrogels through multifractal logistic type laws

DOI10.1155/2019/4091464MaRDI QIDQ2332548zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Anda-Mihaela Craciun, Mihaela Luminita Barhalescu, M. Agop, Lăcrămioara Ochiuz

Publication date 4 November 2019

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2019/4091464

zbMATH Keywords

drug release kineticsnitrosalicyl-imine-chitosan hydrogels

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Review text

Summary: Drug release is a complex phenomenon due to the large number of interdependent side effects that occur simultaneously, involving strong nonlinear dynamics. Therefore, since their theoretical description is difficult in the classical mathematics modelling, we have built a theoretical model based on logistic type laws, validated by the correlations with the experimental data, in a special case of drug release from hydrogels. The novelty of our approach is the implementation of multifractality in logistic type laws, situation in which any chaotic system, characterized by a small number of nonlinear interactions, gets memory and, implicitly, characterization through a large number of nonlinear interactions. In other words, the complex system polymer-drug matrix becomes ``pseudo-intelligent.

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Cites work

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Cited in

(1)

• The incorporation of fractal kinetics in the PK modeling of chemotherapeutic drugs with nonlinear concentration-time profiles

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