Highly efficient factorial designs for cDNA microarray experiments: use of approximate theory together with a step-up step-down procedure
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Abstract: A general method for obtaining highly efficient factorial designs of relatively small sizes is developed for cDNA microarray experiments. The method allows the main effects and interactions of successive orders to be of possibly unequal importance. First, the approximate theory is em-ployed to get an optimal design measure which is then discretized. It is, however, observed that a na"ive discretization may fail to yield an exact design of the stipulated size and, even when it yields such an exact design, there is often scope for improvement in efficiency. To address these issues, we propose a step-up/down procedure which is seen to work very well. The resulting highly efficient designs are found to remain almost free from possible dye-color effects under a suitable dye-color assignment. They are also seen to be quite robust to heteroscedasticity as may be caused by biological variability. We focus on the baseline and all-to-next parametrizations but our method works equally well also for hybrids of the two and other parametrizations.
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Cites work
- A modern theory of factorial designs.
- Design Considerations for Efficient and Effective Microarray Studies
- Efficient design and analysis of two colour factorial microarray experiments
- Experimental design for gene expression microarrays
- Factorial and time course designs for cDNA microarray experiments
- scientific article; zbMATH DE number 3734989 (Why is no real title available?)
- Optimal designs for 2-color microarray experiments
- OPTIMAL DESIGNS FOR TWO-COLOUR MICROARRAY EXPERIMENTS
- Optimal factorial designs for CDNA microarray experiments
Cited in
(10)- Robust multistratum baseline designs
- Optimal design measures under asymmetric errors, with application to binary design points
- Optimal factorial designs for CDNA microarray experiments
- Approximate theory-aided robust efficient factorial fractions under baseline parametrization
- Balanced Factorial Designs for cDNA Microarray Experiments
- Efficiency and robustness issues in complex statistical designs for two-color microarray experi\-ments.
- Factorial and time course designs for cDNA microarray experiments
- Q_B-optimal two-level designs for the baseline parameterization
- Robust and efficient factorial designs under baseline parametrization
- Efficient design and analysis of two colour factorial microarray experiments
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