Optimal factorial designs for CDNA microarray experiments
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Publication:2482985
Abstract: We consider cDNA microarray experiments when the cell populations have a factorial structure, and investigate the problem of their optimal designing under a baseline parametrization where the objects of interest differ from those under the more common orthogonal parametrization. First, analytical results are given for the factorial. Since practical applications often involve a more complex factorial structure, we next explore general factorials and obtain a collection of optimal designs in the saturated, that is, most economic, case. This, in turn, is seen to yield an approach for finding optimal or efficient designs in the practically more important nearly saturated cases. Thereafter, the findings are extended to the more intricate situation where the underlying model incorporates dye-coloring effects, and the role of dye-swapping is critically examined.
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Cited in
(18)- scientific article; zbMATH DE number 5769463 (Why is no real title available?)
- A systematic construction of compromise designs under baseline parameterization
- Optimal biased weighing designs and two-level main-effect plans
- Selecting baseline designs using a minimum aberration criterion when some two-factor interactions are important
- Robust multistratum baseline designs
- Optimal factorial designs for CDNA microarray experiments
- Experimental designs for 2‐colour cDNA microarray experiments
- Efficient design and analysis of two colour factorial microarray experiments
- Sequential Design for Microarray Experiments
- Compromise designs under baseline parameterization
- \(A\)- and \(D\)-optimal row-column designs for two-colour cDNA microarray experiments using linear mixed effects models
- Approximate theory-aided robust efficient factorial fractions under baseline parametrization
- Experimental design for gene expression microarrays
- Algorithmic search for baseline minimum aberration designs
- Balanced Factorial Designs for cDNA Microarray Experiments
- Highly efficient factorial designs for cDNA microarray experiments: use of approximate theory together with a step-up step-down procedure
- Factorial and time course designs for cDNA microarray experiments
- Relationship between orthogonal and baseline parameterizations and its applications to design constructions
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