Optimal weekly scheduling in fractionated radiotherapy: effect of an upper bound on the dose fraction size

DOI10.1007/S00285-014-0805-8MaRDI QIDQ2355786zbMATH OpenOpenAlexWikidataFDO

Authors C. Bruni, Francesco Conte, F. Papa, Carmela Sinisgalli

Publication date 28 July 2015

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-014-0805-8

zbMATH Keywords

nonlinear programmingnonconvex programminglinear-quadratic modelcancer radiotherapy

Mathematics Subject Classification ID

Applications of mathematical programming (90C90) Nonconvex programming, global optimization (90C26) Nonlinear programming (90C30) General biology and biomathematics (92B05)

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Cites work

• scientific article; zbMATH DE number 3325981 (Why is no real title available?)
• A four-dimensional simulation model of tumour response to radiotherapy in vivo: parametric validation considering radiosensitivity, genetic profile and fractionation
• Erratum to: ``Optimal solution for a cancer radiotherapy problem
• Influence of time-dependent stochastic heterogeneity on the radiation response of a cell population
• Linear quadratic and tumour control probability modelling in external beam radiotherapy
• Multi-input optimal control problems for combined tumor anti-angiogenic and radiotherapy treatments
• Optimal solution for a cancer radiotherapy problem
• Reoxygenation and split-dose response to radiation in a tumour model with Krogh-type vascular geometry
• Response of tumor spheroids to radiation: Modeling and parameter estimation

Cited in

(6)

• Optimization of radiation dosing schedules for proneural glioblastoma
• Optimal fractionation in radiotherapy with multiple normal tissues
• Optimal number and sizes of the doses in fractionated radiotherapy according to the LQ model
• Analytical solution to the radiotherapy fractionation problem including dose bound constraints
• Optimization of radiation therapy fractionation schedules in the presence of tumor repopulation
• Optimal control for a bone metastasis with radiotherapy model using a linear objective functional

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