Optimization of radiation therapy fractionation schedules in the presence of tumor repopulation
From MaRDI portal
Publication:2802256
DOI10.1287/IJOC.2015.0659zbMATH Open1338.90440arXiv1312.1332OpenAlexW1612099526MaRDI QIDQ2802256FDOQ2802256
Jan Unkelbach, John N. Tsitsiklis, Jagdish Ramakrishnan, Thomas Bortfeld
Publication date: 25 April 2016
Published in: INFORMS Journal on Computing (Search for Journal in Brave)
Abstract: We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation towards the end of radiation treatment, which is believed to play a role in treatment failure for some tumor sites. A dynamic programming framework is developed to determine an optimal fractionation scheme based on a model of cell kill due to radiation and tumor growth in between treatment days. We find that faster tumor growth suggests shorter overall treatment duration. In addition, the presence of accelerated repopulation suggests larger dose fractions later in the treatment to compensate for the increased tumor proliferation. We prove that the optimal dose fractions are increasing over time. Numerical simulations indicate potential for improvement in treatment effectiveness.
Full work available at URL: https://arxiv.org/abs/1312.1332
Cites Work
- Mathematical derivation of optimal uniform treatment schedules for the fractionated irradiation of human tumors
- Optimal solution for a cancer radiotherapy problem
- Title not available (Why is that?)
- A stochastic control formalism for dynamic biologically conformal radiation therapy
- Mathematical approaches to optimization of cancer chemotherapy
- Linear quadratic and tumour control probability modelling in external beam radiotherapy
- Title not available (Why is that?)
- Fractionation in radiation treatment planning
- A theoretical and computational method for determining optimal treatment schedules in fractionated radiation therapy
- Spatiotemporally Optimal Fractionation in Radiotherapy
- A two-variable linear program solves the standard linear-quadratic formulation of the fractionation problem in cancer radiotherapy
- Stochastic programming for off-line adaptive radiotherapy
Cited In (12)
- Title not available (Why is that?)
- Spatiotemporally Optimal Fractionation in Radiotherapy
- Optimal Fractionation in Radiotherapy
- Adjustable robust treatment-length optimization in radiation therapy
- Optimization of antitumor radiotherapy fractionation via mathematical modeling with account of 4 R's of radiobiology
- Temporal optimization of radiation therapy to heterogeneous tumour populations and cancer stem cells
- Repopulation of Tumour Cells during Radiotherapy Is Doubled during Treatment Gaps
- The evolution of tumour composition during fractionated radiotherapy: implications for outcome
- Operator splitting for adaptive radiation therapy with nonlinear health dynamics
- Analytical solution to the radiotherapy fractionation problem including dose bound constraints
- Optimizing Chemoradiotherapy to Target Metastatic Disease and Tumor Growth
- Robust spatiotemporally integrated fractionation in radiotherapy
Recommendations
- Spatiotemporally Optimal Fractionation in Radiotherapy 👍 👎
- Optimization of radiation therapy in a model for a heterogeneous population of tumor cells 👍 👎
- Temporal optimization of radiation therapy to heterogeneous tumour populations and cancer stem cells 👍 👎
- Scalable Optimization Methods for Incorporating Spatiotemporal Fractionation into Intensity-Modulated Radiotherapy Planning 👍 👎
- Optimization of antitumor radiotherapy fractionation via mathematical modeling with account of 4 R's of radiobiology 👍 👎
- Optimal weekly scheduling in fractionated radiotherapy: effect of an upper bound on the dose fraction size 👍 👎
- Optimal fractionation in radiotherapy with multiple normal tissues 👍 👎
- Multistage stochastic fractionated intensity modulated radiation therapy planning 👍 👎
- Mathematical modeling of the effects of tumor heterogeneity on the efficiency of radiation treatment schedule 👍 👎
- Optimization models for radiotherapy patient scheduling 👍 👎
This page was built for publication: Optimization of radiation therapy fractionation schedules in the presence of tumor repopulation
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2802256)
