Optimal fractionation in radiotherapy with multiple normal tissues

DOI10.1093/IMAMMB/DQV015MaRDI QIDQ4687151zbMATH OpenOpenAlexWikidataFDO

Authors Fatemeh Saberian, Archis Ghate, Minsun Kim

Publication date 11 October 2018

Published in Mathematical Medicine and Biology (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/a3e8506ebad030fca0d310c14518023db15a2862

zbMATH Keywords

intensity modulated radiation therapylinear-quadratic cell survival modelquadratically constrained quadratic programming

Mathematics Subject Classification ID

Mixed integer programming (90C11) Quadratic programming (90C20) Medical applications (general) (92C50)

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(14)

• The evolution of tumour composition during fractionated radiotherapy: implications for outcome
• Robust spatiotemporally integrated fractionation in radiotherapy
• Adjustable robust treatment-length optimization in radiation therapy
• Analytical solution to the radiotherapy fractionation problem including dose bound constraints
• Optimal weekly scheduling in fractionated radiotherapy: effect of an upper bound on the dose fraction size
• Optimization of radiation therapy fractionation schedules in the presence of tumor repopulation
• Selecting radiotherapy dose distributions by means of constrained optimization problems
• Spatiotemporally optimal fractionation in radiotherapy
• Optimal radiation beam profiles considering the stochastic process of patient positioning in fractionated radiation therapy
• Optimal number and sizes of the doses in fractionated radiotherapy according to the LQ model
• Operator splitting for adaptive radiation therapy with nonlinear health dynamics
• A theoretical framework for learning tumor dose-response uncertainty in individualized spatiobiologically integrated radiotherapy
• Value of intermediate imaging in adaptive robust radiotherapy planning to manage radioresistance
• Optimal interventions in robust optimization with time-dependent uncertainties

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