T cell anergy as a strategy to reduce the risk of autoimmunity

DOI10.1016/J.JTBI.2011.02.014MaRDI QIDQ2413871zbMATH OpenOpenAlexWikidataFDO

Authors Koichi Saeki, Yoh Iwasa

Publication date 17 September 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2011.02.014

zbMATH Keywords

Bayesian immunologydecision-making by T cellsself-non-self-discrimination

Mathematics Subject Classification ID

Physiology (general) (92C30) Cell biology (92C37)

Recommendations

• The impact of multiple T cell\,-\,APC encounters and the role of anergy
• Optimal T cell cross-reactivity and the role of regulatory T cells
• Optimal number of regulatory T cells
• Thymic Presentation of Autoantigens and the Efficiency of Negative Selection
• Anergy in self-directed B lymphocytes: a statistical mechanics perspective

Cites work

• Advantage of having regulatory T cells requires localized suppression of immune reactions
• Dynamic optimization of host defense, immune memory, and post-infection pathogen levels in mammals
• Immunological self-tolerance: Lessons from mathematical modeling
• Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger
• Optimal number of regulatory T cells
• The impact of multiple T cell\,-\,APC encounters and the role of anergy

Cited in

(5)

• Optimal number of regulatory T cells
• Self-tolerance and autoimmunity in a regulatory T cell model
• The impact of multiple T cell\,-\,APC encounters and the role of anergy
• Anergy in self-directed B lymphocytes: a statistical mechanics perspective
• Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

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