Advantage of having regulatory T cells requires localized suppression of immune reactions

DOI10.1016/J.JTBI.2009.06.020MaRDI QIDQ1625903zbMATH OpenOpenAlexWikidataFDO

Authors Koichi Saeki, Yoh Iwasa

Publication date 26 November 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2009.06.020

zbMATH Keywords

autoimmunityexperience-dependent differentiationlocalized suppressionpre-determined differentiationregulatory T cells

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37)

Recommendations

• Optimal number of regulatory T cells
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Cites work

• Dynamic optimization of host defense, immune memory, and post-infection pathogen levels in mammals
• Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger
• Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses
• Sensibility of the quorum growth thresholds controlling local immune responses
• Tolerance and immunity in a mathematical model of T-cell mediated suppression

Cited in

(2)

• Optimal number of regulatory T cells
• T cell anergy as a strategy to reduce the risk of autoimmunity

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