Optimal number of regulatory T cells

DOI10.1016/J.JTBI.2009.11.012zbMATH Open1406.92117OpenAlexW2061679005WikidataQ57065282 ScholiaQ57065282MaRDI QIDQ1715313FDOQ1715313

Koichi Saeki, Yoh Iwasa

Publication date: 4 February 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2009.11.012

zbMATH Keywords

regulatory T cellsantigen-presenting cellsco-localizationself-tolerance

Mathematics Subject Classification ID

Physiology (general) (92C30) Cell biology (92C37)

Cites Work

• Dynamic optimization of host defense, immune memory, and post-infection pathogen levels in mammals
• Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses
• Tolerance and immunity in a mathematical model of T-cell mediated suppression
• Sensibility of the quorum growth thresholds controlling local immune responses
• Advantage of having regulatory T cells requires localized suppression of immune reactions
• Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger

Cited In (4)

• Optimal T cell cross-reactivity and the role of regulatory T cells
• T cell anergy as a strategy to reduce the risk of autoimmunity
• Mathematical models for immunology: current state of the art and future research directions
• Dynamic Regulation of T Cell Activation by Coupled Feedforward Loops

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