Revisiting a synthetic intracellular regulatory network that exhibits oscillations

DOI10.1007/s00285-019-01346-3zbMath1415.92090arXiv1808.00595OpenAlexW2885247887WikidataQ92721050 ScholiaQ92721050MaRDI QIDQ2420463

Anne Shiu, Jay R. Walton, Jonathan Tyler

Publication date: 6 June 2019

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1808.00595

zbMATH Keywords

Hopf bifurcationgene regulatory networkrepressilatorHurwitz matrixbiological clock

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

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Uses Software

• Matlab
• Optimization Toolbox

Cites Work

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• A generalized model of the repressilator
• The Poincaré-Bendixson theorem for monotone cyclic feedback systems
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• A distribution‐matching method for parameter estimation and model selection in computational biology