Stochastically-induced bistability in chemical reaction systems
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Publication:2454409
Abstract: We study a stochastic two-species chemical reaction system with two mechanisms. One mechanism consists of chemical interactions which govern the overall drift of species amounts in the system; the other mechanism consists of resampling, branching or splitting which makes unbiased perturbative changes to species amounts. Our results show that in a system with a large but bounded capacity, certain combinations of these two types of interactions can lead to stochastically-induced bistability. Depending on the relative magnitudes of the rates of these two sets of interactions, bistability can occur in two distinct ways with different dynamical signatures.
A model of biochemical reaction systems is considered in which chemical interactions of individual molecules are modeled by continuous time Markov jump processes and stochastic biological effects of resampling or cell splitting are taken into account. The authors analyze the limit behavior of the system when its size tends to infinity. It is shown that bistability in the system behavior can occur by two ways. In the first case of ``rare splitting/resampling, the quasi-stable states are determined by the drift of the deterministic approximation for the chemical interaction model. In the case of ``fast splitting/resampling, the quasi-stable states correspond to two extremes for the size of the system.
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