Asymptotic analysis of multiscale approximations to reaction networks
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Publication:997411
DOI10.1214/105051606000000420zbMATH Open1118.92031arXivmath/0508015OpenAlexW3097995899MaRDI QIDQ997411FDOQ997411
Authors: Karen Ball, Thomas G. Kurtz, Lea Popovic, Grzegorz A. Rempala 
Publication date: 6 August 2007
Published in: The Annals of Applied Probability (Search for Journal in Brave)
Abstract: A reaction network is a chemical system involving multiple reactions and chemical species. Stochastic models of such networks treat the system as a continuous time Markov chain on the number of molecules of each species with reactions as possible transitions of the chain. In many cases of biological interest some of the chemical species in the network are present in much greater abundance than others and reaction rate constants can vary over several orders of magnitude. We consider approaches to approximation of such models that take the multiscale nature of the system into account. Our primary example is a model of a cell's viral infection for which we apply a combination of averaging and law of large number arguments to show that the ``slow component of the model can be approximated by a deterministic equation and to characterize the asymptotic distribution of the ``fast components. The main goal is to illustrate techniques that can be used to reduce the dimensionality of much more complex models.
Full work available at URL: https://arxiv.org/abs/math/0508015
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Functional limit theorems; invariance principles (60F17) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80) Continuous-time Markov processes on discrete state spaces (60J27) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Chemical kinetics in thermodynamics and heat transfer (80A30)
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