Accuracy of multiscale reduction for stochastic reaction systems

DOI10.1137/19M1301928zbMATH Open1480.60217arXiv1909.11916OpenAlexW3214529477MaRDI QIDQ5022754FDOQ5022754

Authors: Germán A. Enciso, Jinsu Kim 

Publication date: 19 January 2022

Published in: Multiscale Modeling & Simulation (Search for Journal in Brave)

Abstract: Stochastic models of chemical reaction networks are an important tool to describe and analyze noise effects in cell biology. When chemical species and reaction rates in a reaction system have different orders of magnitude, the associated stochastic system is often modeled in a multiscale regime. It is known that multiscale models can be approximated with a reduced system such as mean field dynamics or hybrid systems, but the accuracy of the approximation remains unknown. In this paper, we estimate the probability distribution of low copy species in multiscale stochastic reaction systems under short-time scale. We also establish an error bound for this approximation. Throughout the manuscript, typical mass action systems are mainly handled, but we also show that the main theorem can extended to general kinetics, which generalizes existing results in the literature. Our approach is based on a direct analysis of the Kolmogorov equation, in contrast to classical approaches in the existing literature.

Full work available at URL: https://arxiv.org/abs/1909.11916

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zbMATH Keywords

stochastic processesweak convergenceerror boundchemical reaction networkschemical master equationmultiscaling approximation

Mathematics Subject Classification ID

Applications of continuous-time Markov processes on discrete state spaces (60J28) Systems biology, networks (92C42) Limit theorems in probability theory (60F99) Continuous-time Markov processes on discrete state spaces (60J27) Cell biology (92C37)

Cites Work

• Markov Chains
• Stability of Markovian processes III: Foster–Lyapunov criteria for continuous-time processes
• Asymptotic analysis of multiscale approximations to reaction networks
• Separation of time-scales and model reduction for stochastic reaction networks
• The Finite State Projection Approach for the Analysis of Stochastic Noise in Gene Networks
• Linear Generalizations of Gronwall's Inequality
• Solving the chemical master equation for monomolecular reaction systems analytically
• Title not available (Why is that?)
• Product-form stationary distributions for deficiency zero chemical reaction networks
• Scaling limits of spatial compartment models for chemical reaction networks
• Quasi-steady-state approximations derived from the stochastic model of enzyme kinetics
• Finite Time Distributions of Stochastically Modeled Chemical Systems with Absolute Concentration Robustness
• Reduction for stochastic biochemical reaction networks with multiscale conservations
• Accurate chemical master equation solution using multi-finite buffers
• Embracing noise in chemical reaction networks

Cited In (16)

• Revisiting moment-closure methods with heterogeneous multiscale population models
• Accuracy limitations and the measurement of errors in the stochastic simulation of chemically reacting systems
• Stochastic approximations of higher-molecular by bi-molecular reactions
• Asymptotic analysis of multiscale approximations to reaction networks
• Error bound for piecewise deterministic processes modeling stochastic reaction systems
• Convergence of Regularized Particle Filters for Stochastic Reaction Networks
• Error analysis of diffusion approximation methods for multiscale systems in reaction kinetics
• Quasi product form approximation for Markov models of reaction networks
• Separation of time-scales and model reduction for stochastic reaction networks
• Reduction for stochastic biochemical reaction networks with multiscale conservations
• Analysis of the Multiplane Method for Stochastic Simulations of Reaction Networks with Fluctuations
• Computational Translation Framework Identifies Biochemical Reaction Networks with Special Topologies and Their Long-Term Dynamics
• Elimination of intermediate species in multiscale stochastic reaction networks
• Sensitivity analysis for multiscale stochastic reaction networks using hybrid approximations
• Accuracy analysis of hybrid stochastic simulation algorithm on linear chain reaction systems
• Error bound for hybrid models of two-scaled stochastic reaction systems

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