Data-driven method for efficient characterization of rare event probabilities in biochemical systems

DOI10.1007/S11538-018-0509-0MaRDI QIDQ2325577zbMATH OpenOpenAlexWikidataFDO

Authors Min K. Roh

Publication date 26 September 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s11538-018-0509-0

zbMATH Keywords

dwSSAGillespie algorithmimportance samplingrare event probability estimationSSAstochastic simulation

Mathematics Subject Classification ID

Computational methods for stochastic equations (aspects of stochastic analysis) (60H35) Computational methods for problems pertaining to biology (92-08) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A multiple time interval finite state projection algorithm for the solution to the chemical master equation
• Asymptotic analysis of multiscale approximations to reaction networks
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• Multilevel hybrid split-step implicit tau-leap
• Multiscale stochastic simulation algorithm with stochastic partial equilibrium assumption for chemically reacting systems
• Optimization of computer simulation models with rare events
• Separation of time-scales and model reduction for stochastic reaction networks

Cited in

(5)

• Stochastic simulation of biochemical systems: in memory of Dan T. Gillespie's contributions
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• Efficient trace generation for rare-event analysis in chemical reaction networks
• Learning-based importance sampling via stochastic optimal control for stochastic reaction networks
• Automated importance sampling via optimal control for stochastic reaction networks: a Markovian projection-based approach

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