Modeling stochastic gene expression under repression

DOI10.1007/S00285-007-0090-XzbMATH Open1125.92026arXivq-bio/0512016OpenAlexW2039434320WikidataQ51914170 ScholiaQ51914170MaRDI QIDQ2460433FDOQ2460433

Authors: Guilherme C. P. Innocentini, J. E. Hornos 

Publication date: 12 November 2007

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin like stochastic model. The effects of transcriptional fluctuations in protein synthesis is probed by coupling transcription and translation by an amplificative interaction. In the presence of repression a new term contributes to the noise which depends on the rate of mRNA production. If the switching time is small compared with the mRNA life time the noise is also small. In general the dumping of protein production by a repressive agent occurs linearly but the fluctuations can show a maxima at intermediate repression. The discrepancy between the switching time, the mRNA degradation and protein degradation is crucial for the repressive control in translation without large fluctuations. The noise profiles obtained here are in quantitative agreement with recent experiments.

Full work available at URL: https://arxiv.org/abs/q-bio/0512016

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zbMATH Keywords

FluctuationsStochasticityTranscriptional regulation

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Applications of branching processes (60J85)

Cites Work

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Cited In (14)

• Protein synthesis driven by dynamical stochastic transcription
• A model of gene expression based on random dynamical systems reveals modularity properties of gene regulatory networks
• Modeling stochastic gene expression in growing cells
• Quantifying gene expression variability arising from randomness in cell division times
• Exact and approximate distributions of protein and mRNA levels in the low-copy regime of gene expression
• Deterministic and stochastic simulations of simple genetic circuits
• On a mathematical model of a repressilator
• Modeling stochastic gene expression under repression
• Modelling Nonstationary Gene Regulatory Processes
• When activators repress and repressors activate: a qualitative analysis of the Shea-Ackers model
• Evaluation of the performance of mechanisms for noise attenuation in a single-gene expression
• Control of noise in gene expression by transcriptional reinitiation
• On amino acid and codon assignment in algebraic models for the genetic code
• A comparative analysis of noise properties of stochastic binary models for a self-repressing and for an externally regulating gene

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