A quantitative model of error accumulation during PCR amplification

DOI10.1016/J.COMPBIOLCHEM.2005.11.002zbMATH Open1102.92026DBLPjournals/candc/PienaarTNV06OpenAlexW2127476843WikidataQ34984902 ScholiaQ34984902MaRDI QIDQ2500355FDOQ2500355

Authors E. Pienaar, M. Theron, Michael Nelson, H. J. Viljoen

Publication date 23 August 2006

Published in Computational Biology and Chemistry (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc1544370

zbMATH Keywords

Polymerase chain reactionCytosine deaminationDepurinationThermal damage

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Biophysics (92C05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A macroscopic kinetic model for DNA polymerase elongation and high-fidelity nucleotide selection
• Principles of rapid polymerase chain reactions: mathematical modeling and experimental verification

Cited in

(6)

• A fundamental study of the PCR amplification of GC-rich DNA templates
• Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process
• Error threshold in RNA quasispecies models with complementation
• Calibration of quantitative PCR assays
• Quantitative PCR: Procedures and precisions
• A general model of error-prone PCR

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