A quantitative model of error accumulation during PCR amplification

DOI10.1016/J.COMPBIOLCHEM.2005.11.002MaRDI QIDQ2500355zbMATH OpenOpenAlexDBLPWikidataFDO

Authors E. Pienaar, M. Theron, Michael Nelson, H. J. Viljoen

Publication date 23 August 2006

Published in Computational Biology and Chemistry (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc1544370

zbMATH Keywords

Polymerase chain reactionCytosine deaminationDepurinationThermal damage

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Biophysics (92C05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A macroscopic kinetic model for DNA polymerase elongation and high-fidelity nucleotide selection
• Principles of rapid polymerase chain reactions: mathematical modeling and experimental verification

Cited in

(6)

• Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process
• Quantitative PCR: Procedures and precisions
• Calibration of quantitative PCR assays
• A general model of error-prone PCR
• Error threshold in RNA quasispecies models with complementation
• A fundamental study of the PCR amplification of GC-rich DNA templates

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