A quantitative model of error accumulation during PCR amplification

DOI10.1016/J.COMPBIOLCHEM.2005.11.002zbMATH Open1102.92026DBLPjournals/candc/PienaarTNV06OpenAlexW2127476843WikidataQ34984902 ScholiaQ34984902MaRDI QIDQ2500355FDOQ2500355

Authors: E. Pienaar, M. Theron, Michael Nelson, H. J. Viljoen 

Publication date: 23 August 2006

Published in: Computational Biology and Chemistry (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc1544370

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zbMATH Keywords

Polymerase chain reactionCytosine deaminationDepurinationThermal damage

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Biophysics (92C05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Principles of rapid polymerase chain reactions: mathematical modeling and experimental verification
• A macroscopic kinetic model for DNA polymerase elongation and high-fidelity nucleotide selection

Cited In (6)

• Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process
• Quantitative PCR: Procedures and precisions
• Calibration of quantitative PCR assays
• A general model of error-prone PCR
• Error threshold in RNA quasispecies models with complementation
• A fundamental study of the PCR amplification of GC-rich DNA templates

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