Robustness analysis of elementary flux modes generated by column generation

DOI10.1016/J.MBS.2015.12.009MaRDI QIDQ254086zbMATHOpenAlexWikidataFDO

Authors Hildur Æsa Oddsdóttir, Erika Hagrot, Véronique Chotteau, Anders Forsgren

Publication date 8 March 2016

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2015.12.009

zbMATH Keywords

least-squaresChinese hamster ovary cellelementary flux modemetabolic networkrobust optimization

Mathematics Subject Classification ID

Applications of mathematical programming (90C90) Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• A simplex approach to solving robust metabolic models with low-dimensional uncertainty
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Cites work

• Fast computation of minimal elementary decompositions of metabolic flux vectors
• Maximizing Submodular Set Functions: Formulations and Analysis of Algorithms
• Robust Optimization of Large-Scale Systems
• Robust Solutions to Least-Squares Problems with Uncertain Data
• Robust optimization
• Selected Topics in Column Generation

Cited in

(3)

• An interval approach for dealing with flux distributions and elementary modes activity patterns
• A simplex approach to solving robust metabolic models with low-dimensional uncertainty
• Stabilized column generation

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Uses Software

• EFMEvolver
• Metatool

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