Modelling the effects of adherence to the HIV fusion inhibitor enfuvirtide

DOI10.1016/J.JTBI.2010.09.039MaRDI QIDQ2632060zbMATH OpenOpenAlexWikidataFDO

Authors Jie Lou, Robert Smith

Publication date 14 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2010.09.039

zbMATH Keywords

adherenceantiretroviral therapyenfuvirtidefusion inhibitorsmathematical model

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Recommendations

• Mathematical modelling of enfuvirtide and protease inhibitors as combination therapy for HIV
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Cites work

• A class age-structured HIV/AIDS model with impulsive drug-treatment strategy
• Can the viral reservoir of latently infected \(CD4^{+}\) T cells be eradicated with antiretroviral HIV drugs?
• Distinct effects of protease and reverse transcriptase inhibition in an immunological model of HIV-1 infection with impulsive drug effects
• Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects
• Dynamics of HIV infection of CD4^ + T cells
• Global behaviour of an age-infection-structured HIV model with impulsive drug-treatment strategy
• Mechanism-based model of the pharmacokinetics of enfuvirtide, an HIV fusion inhibitor
• Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity
• Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: the role of fusion inhibitors in HAART
• Optimal drug treatment regimens for HIV depend on adherence
• Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
• The mathematics of infectious diseases

Cited in

(13)

• Mathematical modelling of enfuvirtide and protease inhibitors as combination therapy for HIV
• Modeling of fusion inhibitor treatment of RSV in African green monkeys
• Mechanism-based model of the pharmacokinetics of enfuvirtide, an HIV fusion inhibitor
• Effect of DAA therapy in hepatitis C treatment -- an impulsive control approach
• A model for SARS-CoV-2 infection with treatment
• A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (\(\mathrm{TNF}-\alpha\) inhibitor) therapy
• Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects
• Impact of combined therapy in HIV-1 treatment: a double impulsive approach
• Analysis of HIV latent infection model with multiple infection stages and different drug classes
• Viral dynamics of an HIV model with pulse antiretroviral therapy and adherence
• Modelling two different therapy strategies for drug T-20 on HIV-1 patients
• Mathematical modelling of HIV-1 transcription inhibition: a comparative study between optimal control and impulsive approach
• Treatment of methanol toxicity through ethanol and folinic acid: a mathematical study

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