Modelling the effects of adherence to the HIV fusion inhibitor enfuvirtide

DOI10.1016/J.JTBI.2010.09.039zbMath1411.92141OpenAlexW2147438634WikidataQ51652043 ScholiaQ51652043MaRDI QIDQ2632060

Jie Lou, Robert J. Smith?

Publication date: 14 May 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2010.09.039

zbMATH Keywords

mathematical modelantiretroviral therapyadherenceenfuvirtidefusion inhibitors

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Related Items (10)

Analysis of HIV latent infection model with multiple infection stages and different drug classes ⋮ Mathematical modelling of enfuvirtide and protease inhibitors as combination therapy for HIV ⋮ Impact of combined therapy in HIV-1 treatment: a double impulsive approach ⋮ Mathematical modelling of HIV-1 transcription inhibition: a comparative study between optimal control and impulsive approach ⋮ A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (\(\mathrm{TNF}-\alpha\) inhibitor) therapy ⋮ Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects ⋮ Modeling of fusion inhibitor treatment of RSV in African green monkeys ⋮ A model for SARS-CoV-2 infection with treatment ⋮ Effect of DAA therapy in hepatitis C treatment -- an impulsive control approach ⋮ Viral dynamics of an HIV model with pulse antiretroviral therapy and adherence

Cites Work

• Distinct effects of protease and reverse transcriptase inhibition in an immunological model of HIV-1 infection with impulsive drug effects
• Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects
• Can the viral reservoir of latently infected \(CD4^{+}\) T cells be eradicated with antiretroviral HIV drugs?
• A class age-structured HIV/AIDS model with impulsive drug-treatment strategy
• Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: the role of fusion inhibitors in HAART
• Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity
• Mechanism-based model of the pharmacokinetics of enfuvirtide, an HIV fusion inhibitor
• Global behaviour of an age-infection-structured HIV model with impulsive drug-treatment strategy
• Dynamics of HIV infection of CD4\(^ +\) T cells
• Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
• Optimal drug treatment regimens for HIV depend on adherence
• The Mathematics of Infectious Diseases

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