Feature genes selection using fuzzy rough uncertainty metric for tumor diagnosis

DOI10.1155/2019/6705648MaRDI QIDQ2632308zbMATH OpenOpenAlexWikidataFDO

Authors Jiucheng Xu, Yun Wang, Keqiang Xu, Tianli Zhang

Publication date 14 May 2019

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2019/6705648

zbMATH Keywords

feature genes selectionfuzzy rough uncertainty metrictumor diagnosis

Mathematics Subject Classification ID

Theory of fuzzy sets, etc. (03E72) Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Review text

Summary: To select more effective feature genes, many existing algorithms focus on the selection and study of evaluation methods for feature genes, ignoring the accurate mapping of original information in data processing. Therefore, for solving this problem, a new model is proposed in this paper: rough uncertainty metric model. First, the fuzzy neighborhood granule of the sample is constructed by combining the fuzzy similarity relation with the neighborhood radius in the rough set, and the rough decision is defined by using the fuzzy similarity relation and the decision equivalence class. Then, the fuzzy neighborhood granule and the rough decision are introduced into the conditional entropy, and the rough uncertainty metric model is proposed; in the meantime, the definition of measuring the significance of feature genes and the proof of some related theorems are given. To make this model tolerate noises in data, this paper introduces a variable precision model and discusses the selection of parameters. Finally, based on the rough uncertainty metric model, we design a feature genes selection algorithm and compare it with some existing similar algorithms. The experimental results show that the proposed algorithm can select the smaller feature genes subset with higher classification accuracy and verify that the model proposed in this paper is more effective.

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Cited in

(6)

• Feature selection using neighborhood entropy-based uncertainty measures for gene expression data classification
• Fuzzy-rough set models and fuzzy-rough data reduction
• Feature selection method based on K-S test and neighborhood rough sets
• Fuzzy-based concept-cognitive learning: an investigation of novel approach to tumor diagnosis analysis
• Fuzzy rough set attribute reduction based on decision ball model
• Sensitivity and specificity based multiobjective approach for feature selection: application to cancer diagnosis

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