Analysis of neural clusters due to deep brain stimulation pulses

DOI10.1007/S00422-020-00850-WzbMATH Open1460.92097DBLPjournals/bc/KuelbsDMM20arXiv2007.02414OpenAlexW3112701107WikidataQ104138820 ScholiaQ104138820MaRDI QIDQ2659622FDOQ2659622

Daniel Kuelbs, Jeff Moehlis, Jacob Dunefsky, Bharat Monga

Publication date: 26 March 2021

Published in: Biological Cybernetics (Search for Journal in Brave)

Abstract: Deep brain stimulation (DBS) is an established method for treating pathological conditions such as Parkinson's disease, dystonia, Tourette syndrome, and essential tremor. While the precise mechanisms which underly the effectiveness of DBS are not fully understood, theoretical studies of populations of neural oscillators stimulated by periodic pulses suggest that this may be related to clustering, in which subpopulations of the neurons are synchronized, but the subpopulations are desynchronized with respect to each other. The details of the clustering behavior depend on the frequency and amplitude of the stimulation in a complicated way. In the present study, we investigate how the number of clusters, their stability properties, and their basins of attraction can be understood in terms of one-dimensional maps defined on the circle. Moreover, we generalize this analysis to stimuli that consist of pulses with alternating properties, which provide additional degrees of freedom in the design of DBS stimuli. Our results illustrate how the complicated properties of clustering behavior for periodically forced neural oscillator populations can be understood in terms of a much simpler dynamical system.

Full work available at URL: https://arxiv.org/abs/2007.02414

zbMATH Keywords

clusteringdeep brain stimulationphase modelsneural oscillators

Mathematics Subject Classification ID

Medical applications (general) (92C50) Neural networks for/in biological studies, artificial life and related topics (92B20)

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Cited In (3)

• Optimal Control of Oscillation Timing and Entrainment Using Large Magnitude Inputs: An Adaptive Phase-Amplitude-Coordinate-Based Approach
• Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model
• Phase response approaches to neural activity models with distributed delay

Uses Software

• XPPAUT

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