A mathematical insight in the epithelial-mesenchymal-like transition in cancer cells and its effect in the invasion of the extracellular matrix
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Publication:285366
DOI10.1007/S00574-016-0147-9zbMATH Open1359.92048arXiv1505.04268OpenAlexW2963837226MaRDI QIDQ285366FDOQ285366
Authors: Nadja Hellmann, Niklas Kolbe, Nikolaos Sfakianakis 
Publication date: 19 May 2016
Published in: Bulletin of the Brazilian Mathematical Society. New Series (Search for Journal in Brave)
Abstract: Current biological knowledge supports the existence of a secondary group of cancer cells within the body of the tumour that exhibits stem cell-like properties. These cells are termed Cancer Stem Cells (CSCs}, and as opposed to the more usual Differentiated Cancer Cells (DCCs), they exhibit higher motility, they are more resilient to therapy, and are able to metastasize to secondary locations within the organism and produce new tumours. The origin of the CSCs is not completely clear; they seem to stem from the DCCs via a transition process related to the Epithelial-Mesenchymal Transition (EMT) that can also be found in normal tissue. In the current work we model and numerically study the transition between these two types of cancer cells, and the resulting "ensemble" invasion of the extracellular matrix. This leads to the derivation and numerical simulation of two systems: an algebraic-elliptic system for the transition and an advection-reaction-diffusion system of Keller-Segel taxis type for the invasion.
Full work available at URL: https://arxiv.org/abs/1505.04268
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Cited In (13)
- A mathematical multi-organ model for bidirectional epithelial–mesenchymal transitions in the metastatic spread of cancer
- Analysis of a reduced model of epithelial-mesenchymal fate determination in cancer metastasis as a singularly-perturbed monotone system
- Existence and uniqueness of global classical solutions to a two dimensional two species cancer invasion haptotaxis model
- A new result for global solvability of a two species cancer invasion haptotaxis model with tissue remodeling
- Global boundedness of classical solutions to a two species cancer invasion haptotaxis model with tissue remodeling
- Global boundedness for a \(N\)-dimensional two species cancer invasion haptotaxis model with tissue remodeling
- An adaptive rectangular mesh administration and refinement technique with application in cancer invasion models
- Global solvability and optimal control to a haptotaxis cancer invasion model with two cancer cell species
- A multiscale approach to the migration of cancer stem cells: mathematical modelling and simulations
- Modeling the influence of cell-cell contact and TGF-\(\beta\) signaling on the epithelial mesenchymal transition in MCF7 breast carcinoma cells
- Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: a mathematical approach
- Global weak solutions in a three-dimensional two-species cancer invasion haptotaxis model without cell proliferation
- Boundedness in a two-dimensional two-species cancer invasion haptotaxis model without cell proliferation
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