Boundedness in a two-dimensional two-species cancer invasion haptotaxis model without cell proliferation

Classical solutions to PDEs (35A09) Asymptotic behavior of solutions to PDEs (35B40) Initial-boundary value problems for second-order parabolic systems (35K51) Quasilinear parabolic equations (35K59) Cell movement (chemotaxis, etc.) (92C17)

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In this paper, the authors consider the two-species cancer invasion haptotaxis model without cell proliferation \[ \begin{aligned} c_{1t} & =\Delta c_1-\chi_1\nabla\cdot (c_1\nabla v)-f(v)mc_1, \\ c_{2t} & = \Delta c_2-\chi_2\nabla\cdot(c_2\nabla v) + f(v)mc_1, \\ \tau m_t & = \Delta m + c_1 + c_2-m, \\ v_t & = -mv + \eta v(1-\alpha_1c_1-\alpha_2c_2-v) \end{aligned} \] in a bounded and smooth domain \(\Omega\subset\mathbb{R}^2\) with homogeneous Neumann conditions, where \(\chi_1, \chi_2, \eta > 0, \tau\in\{0, 1\}\), \(f(v)\in C^1 ([0,\infty); [0,\infty))\) and \(f(0) = 0\). It is well known that the absence of logistic source aggravates mathematical difficulties, which are overcome by constructing a suitable Lyapunov functional. When the remodeling of ECM includes a competition with cancer cells (i.e., \(\alpha_1 = \alpha_2 = 1\)), the authors prove that the associated initial-boundary value problem of the above system with \(\tau = 0\) admits a globally bounded classical solution for suitably small \(\eta\). And when the competition with cancer cells is taken no account in the re-establishment of ECM (i.e., \(\alpha_1 = \alpha_2 = 0\)), the authors establish the global boundedness of classical solution to the corresponding initial-boundary value problem of the above system with \(\tau\in\{0, 1\}\) for arbitrarily large \(\eta\).

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