Asymptotic behavior of solutions to a tumor angiogenesis model with chemotaxis–haptotaxis

DOI10.1142/S0218202519500246MaRDI QIDQ4973287zbMATH OpenOpenAlexFDO

Authors Yifu Wang, Peter Y. H. Pang

Publication date 3 December 2019

Published in M\(^3\)AS. Mathematical Models \& Methods in Applied Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1903.10835

zbMATH Keywords

angiogenesisasymptotic behaviorboundednesschemotaxishaptotaxis

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Stability in context of PDEs (35B35) Asymptotic behavior of solutions to PDEs (35B40) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

Abstract: This paper studies the following system of differential equations modeling tumor angiogenesis in a bounded smooth domain $Omegasubsetmathbb{R}^N$ ($N=1,2$): ${\displaystyle }$label{0} left{�egin{array}{ll} p_t=Delta p-

ablacdotp p(displaystylefrac alpha {1+c} abla c+ ho

abla w)+lambda p(1-p),,& xin Omega, t>0, c_t=Delta c-c-mu pc,, &xin Omega, t>0,\ w_t= gamma p(1-w),,& xin Omega, t>0, end{array} ight. ${\displaystyle }$ where $alpha,ho,lambda,mu$ and $gamma$ are positive parameters. For any reasonably regular initial data $(p_0,c_0,w_0)$, we prove the global boundedness ($L^{i}nfty$-norm) of $p$ via an iterative method. Furthermore, we investigate the long-time behavior of solutions to the above system under an additional mild condition, and improve previously known results. In particular, in the one-dimensional case, we show that the solution $(p,c,w)$ converges to $(1,0,1)$ with an explicit exponential rate as time tends to infinity.

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Cited in

(26)

• An angiogenesis model with nonlinear chemotactic response and flux at the tumor boundary
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