An Optimal Test with Maximum Average Power While Controlling FDR with Application to RNA‐Seq Data

DOI10.1111/biom.12036zbMath1418.62066OpenAlexW2111978032WikidataQ30657447 ScholiaQ30657447MaRDI QIDQ2861943

Peng Liu, Yaqing Si

Publication date: 13 November 2013

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/biom.12036

zbMATH Keywords

empirical BayesRNA-seqgene expressionFDR controlmaximum average power

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric hypothesis testing (62F03) Asymptotic properties of parametric tests (62F05)

Related Items (3)

Shrinkage-based diagonal Hotelling's tests for high-dimensional small sample size data ⋮ A semi-parametric Bayesian approach for differential expression analysis of RNA-seq data ⋮ HmmSeq: a hidden Markov model for detecting differentially expressed genes from RNA-seq data

Uses Software

• BaySeq
• DEseq

Cites Work

• Unnamed Item
• Optimal tests shrinking both means and variances applicable to microarray data analysis
• Small-sample estimation of negative binomial dispersion, with applications to SAGE data
• Maximum Average-Power (MAP) Tests
• Statistical significance for genomewide studies

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