Full matching approach to instrumental variables estimation with application to the effect of malaria on stunting
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Publication:288596
DOI10.1214/15-AOAS894zbMATH Open1358.62096arXiv1411.7342OpenAlexW2963187519MaRDI QIDQ288596FDOQ288596
Jürgen May, Benno Kreuels, Hyunseung Kang, Dylan S. Small
Publication date: 27 May 2016
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: Most previous studies of the causal relationship between malaria and stunting have been studies where potential confounders are controlled via regression-based methods, but these studies may have been biased by unobserved confounders. Instrumental variables (IV) regression offers a way to control for unmeasured confounders where, in our case, the sickle cell trait can be used as an instrument. However, for the instrument to be valid, it may still be important to account for measured confounders. The most commonly used instrumental variable regression method, two-stage least squares, relies on parametric assumptions on the effects of measured confounders to account for them. Additionally, two-stage least squares lacks transparency with respect to covariate balance and weighing of subjects and does not blind the researcher to the outcome data. To address these drawbacks, we propose an alternative method for IV estimation based on full matching. We evaluate our new procedure on simulated data and real data concerning the causal effect of malaria on stunting among children. We estimate that the risk of stunting among children with the sickle cell trait decrease by 0.22 times the average number of malaria episodes prevented by the sickle cell trait, a substantial effect of malaria on stunting (p-value: 0.011, 95% CI: 0.044, 1).
Full work available at URL: https://arxiv.org/abs/1411.7342
Nonparametric estimation (62G05) Nonparametric hypothesis testing (62G10) Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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Cited In (7)
- Biased Encouragements and Heterogeneous Effects in an Instrumental Variable Study of Emergency General Surgical Outcomes
- Full matching approach to instrumental variables estimation with application to the effect of malaria on stunting
- Bridging preference‐based instrumental variable studies and cluster‐randomized encouragement experiments: Study design, noncompliance, and average cluster effect ratio
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