Efficient Algorithms for Optimal Designs with Correlated Observations in Pharmacokinetics and Dose-Finding Studies

DOI10.1111/j.1541-0420.2011.01657.xzbMath1241.62156WikidataQ42612807 ScholiaQ42612807MaRDI QIDQ2893997

Tim Holland-Letz, Dette, Holger, Didier Renard

Publication date: 27 June 2012

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2011.01657.x

zbMATH Keywords

random effects; correlated observations; dose-finding studies; locally optimal design; heteroscedastic regression; multiplicative algorithms; population pharmacokinetics

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

62K05: Optimal statistical designs

62H20: Measures of association (correlation, canonical correlation, etc.)

92C45: Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)

Related Items

On the combination of c‐ and D‐optimal designs: General approaches and applications in dose–response studies, Evaluation of Combinatorial Optimisation Algorithms for c-Optimal Experimental Designs with Correlated Observations

Cites Work

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