Efficient algorithms for optimal designs with correlated observations in pharmacokinetics and dose-finding studies

DOI10.1111/J.1541-0420.2011.01657.XzbMATH Open1241.62156OpenAlexW2083097762WikidataQ42612807 ScholiaQ42612807MaRDI QIDQ2893997FDOQ2893997

Authors: Tim Holland-Letz, Holger Dette, Didier Renard 

Publication date: 27 June 2012

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2011.01657.x

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zbMATH Keywords

random effectsdose-finding studiescorrelated observationslocally optimal designheteroscedastic regressionmultiplicative algorithmspopulation pharmacokinetics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Measures of association (correlation, canonical correlation, etc.) (62H20) Optimal statistical designs (62K05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Title not available (Why is that?)
• General equivalence theory for optimum designs (approximate theory)
• Construction of optimal designs using a clustering approach
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• Improvements on removing nonoptimal support points in \(D\)-optimum design algorithms
• Improving updating rules in multiplicative algorithms for computing \(D\)-optimal designs
• Monotonic convergence of a general algorithm for computing optimal designs
• Optimal Bayesian design applied to logistic regression experiments
• Title not available (Why is that?)
• Locally Optimal Designs for Estimating Parameters
• Optimal Design of Experiments
• Optimal design in random-effects regression models
• Dose finding in drug development.
• Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models
• Approximate D-optimal designs of experiments on the convex hull of a finite set of information matrices
• Further Developments of the Fisher Information Matrix in Nonlinear Mixed Effects Models with Evaluation in Population Pharmacokinetics

Cited In (4)

• Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics
• On the combination of \(c\)- and \(D\)-optimal designs: general approaches and applications in dose-response studies
• Evaluation of Combinatorial Optimisation Algorithms for c-Optimal Experimental Designs with Correlated Observations
• Optimal designs for two nested pharmacokinetic models with correlated observations

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