Optimal therapy protocols in the mathematical model of acute leukemia with several phase constraints

DOI10.1002/OCA.2087MaRDI QIDQ2931071zbMATH OpenOpenAlexFDO

Authors Y. Todorov, F. Nuernberg

Publication date 21 November 2014

Published in Optimal Control Applications \& Methods (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/oca.2087

zbMATH Keywords

optimal controlphase constraintsacute myeloid leukemiatherapy protocols

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15) Applications of optimal control and differential games (49N90)

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Cites work

• A Cell Kinetics Justification for Gompertz’ Equation
• A history of the study of solid tumour growth: the contribution of mathematical modelling
• A mathematical model of neutrophil production and control in normal man
• Acute leukemia and chemotherapy: A modeling viewpoint
• An optimal strategy for leukemia therapy: a multi-objective approach
• Combining Gompertzian growth and cell population dynamics
• Gompertzian growth as a consequence of tumor heterogeneity
• On strategies on a mathematical model for leukemia therapy
• Optimal control analysis in the chemotherapy of IgG multiple myeloma

Cited in

(8)

• An optimal strategy for leukemia therapy: a multi-objective approach
• Optimization of combination therapy for chronic myeloid leukemia with dosing constraints
• Optimal control in a mathematical model for leukemia therapy with phase constraints
• On optimal and suboptimal treatment strategies for a mathematical model of leukemia
• Optimal multitherapy strategy in mathematical model of dynamics of the number of nonuniform tumor cells
• Mathematical models of leukaemia and its treatment: a review
• Optimal control of treatment in a mathematical model of chronic myelogenous leukemia
• On strategies on a mathematical model for leukemia therapy

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