Optimal therapy protocols in the mathematical model of acute leukemia with several phase constraints

DOI10.1002/oca.2087zbMath1302.49058OpenAlexW1933519410MaRDI QIDQ2931071

F. Nürnberg, Y. Todorov

Publication date: 21 November 2014

Published in: Optimal Control Applications and Methods (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/oca.2087

zbMATH Keywords

optimal controlphase constraintsacute myeloid leukemiatherapy protocols

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15)

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Cites Work

• A history of the study of solid tumour growth: the contribution of mathematical modelling
• On strategies on a mathematical model for leukemia therapy
• Gompertzian growth as a consequence of tumor heterogeneity
• A mathematical model of neutrophil production and control in normal man
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Acute leukemia and chemotherapy: A modeling viewpoint
• Combining Gompertzian growth and cell population dynamics
• An optimal strategy for leukemia therapy: a multi-objective approach
• A Cell Kinetics Justification for Gompertz’ Equation

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