Optimization of combination therapy for chronic myeloid leukemia with dosing constraints

DOI10.1007/S00285-018-1262-6MaRDI QIDQ1789085zbMATH OpenOpenAlexWikidataFDO

Authors Helen Moore, Lewis Strauss, Urszula Ledzewicz

Publication date 9 October 2018

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-018-1262-6

zbMATH Keywords

constrained optimizationoptimal controlimmunotherapycombination therapychronic myeloid leukemia (CML)tyrosine kinase inhibitors (TKIs)

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15) Variational principles of physics (49S05) Cell movement (chemotaxis, etc.) (92C17)

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Cites work

• scientific article; zbMATH DE number 3191476 (Why is no real title available?)
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Cited in

(7)

• Optimal control of combination immunotherapy for a virtual murine cohort in a glioblastoma-immune dynamics model
• On the role of the objective in the optimization of compartmental models for biomedical therapies
• On the role of pharmacometrics in mathematical models for cancer treatments
• Optimization of combined leukemia therapy by finite-dimensional optimal control modeling
• An optimization method for treating solid tumors with combined therapy using the great deluge algorithm
• An optimal strategy for leukemia therapy: a multi-objective approach
• Chemo and immunotherapy effects on stability regions of tumor models

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