A comparison between the diffusion-reaction and slow axonal transport models for predicting tau distribution along an axon

DOI10.1093/IMAMMB/DQU003MaRDI QIDQ2949685zbMATH OpenOpenAlexWikidataFDO

Authors I. A. Kuznetsov, A. V. Kuznetsov

Publication date 2 October 2015

Published in Mathematical Medicine and Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1093/imammb/dqu003

zbMATH Keywords

analytical solutiondiffusion-reaction modeltau proteinslow axonal transport model

Mathematics Subject Classification ID

Neural biology (92C20) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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(13)

• Simulating the effect of formation of amyloid plaques on aggregation of tau protein
• Utilization of the bootstrap method for determining confidence intervals of parameters for a model of MAP1B protein transport in axons
• A Stochastic Compartmental Model for Fast Axonal Transport
• Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport
• What tau distribution maximizes fast axonal transport toward the axonal synapse?
• Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data
• Modeling tau transport in the axon initial segment
• Analytical comparison between Nixon-Logvinenko's and Jung-Brown's theories of slow neurofilament transport in axons
• Comparison of active transport in neuronal axons and dendrites
• What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons?
• How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study
• An exact solution describing slow axonal transport of cytoskeletal elements: the effect of a finite half-life
• Bidirectional, unlike unidirectional transport, allows transporting axonal cargos against their concentration gradient

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