Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data

DOI10.1098/RSPA.2017.0045zbMath1404.92055OpenAlexW2610739416WikidataQ53240962 ScholiaQ53240962MaRDI QIDQ4647217

Ivan A. Kuznetsov, Andrey V. Kuznetsov

Publication date: 4 January 2019

Published in: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1098/rspa.2017.0045

zbMATH Keywords

mathematical modellingAlzheimer's diseasebootstrappingneuronresampling residualstau protein

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Neural biology (92C20)

Related Items (5)

Bidirectional, unlike unidirectional transport, allows transporting axonal cargos against their concentration gradient ⋮ How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study ⋮ Utilization of the bootstrap method for determining confidence intervals of parameters for a model of MAP1B protein transport in axons ⋮ Modeling tau transport in the axon initial segment ⋮ Simulating the effect of formation of amyloid plaques on aggregation of tau protein

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• What tau distribution maximizes fast axonal transport toward the axonal synapse?
• Past and future of inverse problems
• A comparison between the diffusion–reaction and slow axonal transport models for predicting tau distribution along an axon
• Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport
• What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons?
• An exact solution describing slow axonal transport of cytoskeletal elements: the effect of a finite half-life

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