Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations

DOI10.1016/J.MBS.2016.03.006zbMATH Open1343.92189OpenAlexW2312117632WikidataQ50682686 ScholiaQ50682686MaRDI QIDQ299385FDOQ299385

Authors: Fedor A. Balabin, Anastasia N. Sveshnikova 

Publication date: 22 June 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2016.03.006

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zbMATH Keywords

negative feedbackpositive feedbackblood plateletcalcium signaling

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08) Biological rhythms and synchronization (92B25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Feedback control (93B52)

Cites Work

• A mathematical model of spontaneous calcium(II) oscillations in astrocytes
• Feedback loops shape cellular signals in space and time

Cited In (2)

• A modular systems biological modelling framework studies cyclic nucleotide signaling in platelets
• Amplification and oscillations in the FAK/Src kinase system during integrin signaling

Uses Software

• COPASI

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