Travelling wave analysis of a mathematical model of glioblastoma growth
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Abstract: In this paper we analyse a previously proposed cell-based model of glioblastoma (brain tumour) growth, which is based on the assumption that the cancer cells switch phenotypes between a proliferative and motile state (Gerlee and Nelander, PLoS Comp. Bio., 8(6) 2012). The dynamics of this model can be described by a system of partial differential equations, which exhibits travelling wave solutions whose wave speed depends crucially on the rates of phenotypic switching. We show that under certain conditions on the model parameters, a closed form expression of the wave speed can be obtained, and using singular perturbation methods we also derive an approximate expression of the wave front shape. These new analytical results agree with simulations of the cell-based model, and importantly show that the inverse relationship between wave front steepness and speed observed for the Fisher equation no longer holds when phenotypic switching is considered.
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Cites work
- scientific article; zbMATH DE number 42093 (Why is no real title available?)
- Biological invasion of an organism with separate mobile and stationary states: Modelling and analysis
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Cited in
(25)- Patient-specific parameter estimates of glioblastoma multiforme growth dynamics from a model with explicit birth and death rates
- Phenotypic switching mechanisms determine the structure of cell migration into extracellular matrix under the `go-or-grow' hypothesis
- Pattern formation and travelling waves in a multiphase moving boundary model of tumour growth
- Speed switch in glioblastoma growth rate due to enhanced hypoxia-induced migration
- Traveling waves in a coarse‐grained model of volume‐filling cell invasion: Simulations and comparisons
- Invasion fronts and adaptive dynamics in a model for the growth of cell populations with heterogeneous mobility
- Exact travelling wave solutions of non-linear reaction-convection-diffusion equations—An Abel equation based approach
- Nonlinear waves in a simple model of high-grade glioma
- A mathematical modelling study of chemotactic dynamics in cell cultures: the impact of spatio-temporal heterogeneity
- Travelling wave solutions of the reaction-diffusion mathematical model of glioblastoma growth: an Abel equation based approach
- Existence of traveling wave solutions to data-driven glioblastoma multiforme growth models with density-dependent diffusion
- Travelling waves due to negative plant-soil feedbacks in a model including tree life-stages
- Improved model prediction of glioma growth utilizing tissue-specific boundary effects
- Travelling waves in a minimal go-or-grow model of cell invasion
- Mathematical modeling of brain metastases growth and response to therapies: a review
- An imaging-informed mechanical framework to provide a quantitative description of brain tumour growth and the subsequent deformation of white matter tracts
- Nonlinear ghost waves accelerate the progression of high-grade brain tumors
- Stability analysis of a mathematical model for glioma-immune interaction under optimal therapy
- Traveling wave speed and profile of a ``go or grow glioblastoma multiforme model
- Travelling waves for low-grade glioma growth and response to a chemotherapy model
- On a reaction-cross-diffusion system modeling the growth of glioblastoma
- Traveling waves of a Go-or-Grow model of glioma growth
- NUMERICAL ASSESSMENT OF THE BRAIN TUMOR GROWTH MODEL VIA FIBONACCI AND HAAR WAVELETS
- Proliferation of cells with aggregation and communication
- Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations
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