Travelling wave analysis of a mathematical model of glioblastoma growth
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Publication:299388
DOI10.1016/J.MBS.2016.03.004zbMATH Open1343.92221arXiv1305.5036OpenAlexW1852643791WikidataQ50681617 ScholiaQ50681617MaRDI QIDQ299388FDOQ299388
Authors: Philip Gerlee, Sven Nelander 
Publication date: 22 June 2016
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: In this paper we analyse a previously proposed cell-based model of glioblastoma (brain tumour) growth, which is based on the assumption that the cancer cells switch phenotypes between a proliferative and motile state (Gerlee and Nelander, PLoS Comp. Bio., 8(6) 2012). The dynamics of this model can be described by a system of partial differential equations, which exhibits travelling wave solutions whose wave speed depends crucially on the rates of phenotypic switching. We show that under certain conditions on the model parameters, a closed form expression of the wave speed can be obtained, and using singular perturbation methods we also derive an approximate expression of the wave front shape. These new analytical results agree with simulations of the cell-based model, and importantly show that the inverse relationship between wave front steepness and speed observed for the Fisher equation no longer holds when phenotypic switching is considered.
Full work available at URL: https://arxiv.org/abs/1305.5036
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Cited In (25)
- Patient-specific parameter estimates of glioblastoma multiforme growth dynamics from a model with explicit birth and death rates
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- Travelling wave solutions of the reaction-diffusion mathematical model of glioblastoma growth: an Abel equation based approach
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- Pattern formation and travelling waves in a multiphase moving boundary model of tumour growth
- Exact travelling wave solutions of non-linear reaction-convection-diffusion equations—An Abel equation based approach
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- Nonlinear ghost waves accelerate the progression of high-grade brain tumors
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- Nonlinear waves in a simple model of high-grade glioma
- NUMERICAL ASSESSMENT OF THE BRAIN TUMOR GROWTH MODEL VIA FIBONACCI AND HAAR WAVELETS
- Existence of traveling wave solutions to data-driven glioblastoma multiforme growth models with density-dependent diffusion
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- Speed switch in glioblastoma growth rate due to enhanced hypoxia-induced migration
- A mathematical modelling study of chemotactic dynamics in cell cultures: the impact of spatio-temporal heterogeneity
- Travelling waves for low-grade glioma growth and response to a chemotherapy model
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