Feedback regulation in a cancer stem cell model can cause an Allee effect

DOI10.1007/s11538-016-0161-5zbMath1341.92029OpenAlexW2343285928WikidataQ37097913 ScholiaQ37097913MaRDI QIDQ301562

Thomas Hillen, Anna Konstorum, John S. Lowengrub

Publication date: 30 June 2016

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4946570

zbMATH Keywords

Allee effectcancer stem celltumor extinctionstable manifold theorem

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Related Items (9)

Is the Allee effect relevant in cancer evolution and therapy? ⋮ Mathematical modeling of the role of \textit{survivin} on dedifferentiation and radioresistance in cancer ⋮ Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation ⋮ Stability of control networks in autonomous homeostatic regulation of stem cell lineages ⋮ Determining the control networks regulating stem cell lineages in colonic crypts ⋮ Effect of feedback regulation on stem cell fractions in tissues and tumors: understanding chemoresistance in cancer ⋮ Dynamic analysis of a tumor-immune system under Allee effect ⋮ Resilience analysis for competing populations ⋮ Do mechanisms matter? Comparing cancer treatment strategies across mathematical models and outcome objectives

Cites Work

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• Mathematical modeling of the role of \textit{survivin} on dedifferentiation and radioresistance in cancer
• The tumor growth paradox and immune system-mediated selection for cancer stem cells
• Analysis of tracer particle migration in inhomogeneous turbulence
• Multispecies model of cell lineages and feedback control in solid tumors

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