On high-dimensional misspecified mixed model analysis in genome-wide association study

DOI10.1214/15-AOS1421zbMATH Open1358.62095MaRDI QIDQ342680FDOQ342680

Authors: Cong Li, Debashis Paul, Can Yang, Jiming Jiang, Hongyu Zhao 

Publication date: 18 November 2016

Published in: The Annals of Statistics (Search for Journal in Brave)

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zbMATH Keywords

heritabilityrandom matrix theoryvariance componentsasymptotic propertyestimatorgenetic implicationsmisspecified linear mixed model (LMM)MMMArestricted maximum likelihood (REML)

Mathematics Subject Classification ID

Point estimation (62F10) General nonlinear regression (62J02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20) Random matrices (probabilistic aspects) (60B20)

Cited In (21)

• Best look-alike prediction: another look at the Bayesian classifier and beyond
• Estimating Trans-Ancestry Genetic Correlation with Unbalanced Data Resources
• Learning from a lot: empirical Bayes for high-dimensional model-based prediction
• Maximum likelihood for Gaussian process classification and generalized linear mixed models under case-control sampling
• Heritability estimation in case-control studies
• On blockwise and reference panel-based estimators for genetic data prediction in high dimensions
• On Genetic Correlation Estimation With Summary Statistics From Genome-Wide Association Studies
• On polygenic risk scores for complex traits prediction
• High-Dimensional Asymptotic Behavior of Inference Based on Gwas Summary Statistics
• Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies
• Cross-Trait Prediction Accuracy of Summary Statistics in Genome-Wide Association Studies
• A unified framework for variance component estimation with summary statistics in genome-wide association studies
• High-dimensional linear models: a random matrix perspective
• Estimation of variance components, heritability and the ridge penalty in high-dimensional generalized linear models
• Inference and Estimation for Random Effects in High-Dimensional Linear Mixed Models
• Simple measures of uncertainty for model selection
• Variance estimation and confidence intervals from genome-wide association studies through high-dimensional misspecified mixed model analysis
• Inference for High-Dimensional Linear Mixed-Effects Models: A Quasi-Likelihood Approach
• WONDER: weighted one-shot distributed ridge regression in high dimensions
• Statistical properties of simple random-effects models for genetic heritability
• Distributed Bayesian Inference in Linear Mixed-Effects Models

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