A unified framework for variance component estimation with summary statistics in genome-wide association studies

DOI10.1214/17-AOAS1052zbMATH Open1383.62305OpenAlexW2951217122WikidataQ52668235 ScholiaQ52668235MaRDI QIDQ127747FDOQ127747

Authors: Xiang Zhou, Peng Zhang 

Publication date: 1 December 2017

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://projecteuclid.org/euclid.aoas/1514430276

Recommendations

• On high-dimensional misspecified mixed model analysis in genome-wide association study
• A simple, consistent estimator of SNP heritability from genome-wide association studies
• Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies
• Confidence intervals for heritability via Haseman-Elston regression
• Linear Score Tests for Variance Components in Linear Mixed Models and Applications to Genetic Association Studies

zbMATH Keywords

method of momentslinear mixed modelgenome-wide association studiesMINQUEsummary statisticsvariance component

Mathematics Subject Classification ID

Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Cited In (8)

• Variable prioritization in nonlinear black box methods: a genetic association case study
• A simple, consistent estimator of SNP heritability from genome-wide association studies
• An algorithm for searching optimal variance component estimators in linear mixed models
• A Penalized Regression Framework for Building Polygenic Risk Models Based on Summary Statistics From Genome-Wide Association Studies and Incorporating External Information
• REMI: REGRESSION WITH MARGINAL INFORMATION AND ITS APPLICATION IN GENOME-WIDE ASSOCIATION STUDIES
• GEMMA
• Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies
• rMVP

This page was built for publication: A unified framework for variance component estimation with summary statistics in genome-wide association studies

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q127747)