A Penalized Regression Framework for Building Polygenic Risk Models Based on Summary Statistics From Genome-Wide Association Studies and Incorporating External Information

DOI10.1080/01621459.2020.1764849zbMath1457.62337OpenAlexW3022618057MaRDI QIDQ5857106

Ting-Huei Chen, Maria Teresa Landi, Jianxin Shi, Nilanjan Chatterjee

Publication date: 30 March 2021

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414872

zbMATH Keywords

summary statisticsLassogenome wide association studypolygenic risk scoregenetic pleiotropygenetic risk prediction

Mathematics Subject Classification ID

Ridge regression; shrinkage estimators (Lasso) (62J07) Applications of statistics to biology and medical sciences; meta analysis (62P10) Learning and adaptive systems in artificial intelligence (68T05)

Related Items

PANPRSnext

Uses Software

• glmnet
• SummaryAUC
• LDAK

Cites Work

• Coordinate descent algorithms for nonconvex penalized regression, with applications to biological feature selection
• Designing penalty functions in high dimensional problems: the role of tuning parameters
• Penalized regression and risk prediction in genome‐wide association studies
• Model Selection and Estimation in Regression with Grouped Variables
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