Spatio-temporal models of lymphangiogenesis in wound healing
From MaRDI portal
(Redirected from Publication:347055)
Abstract: Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for the regeneration of the lymphatic network. Lymphangiogenesis is a markedly different process from angiogenesis, occurring at different times and in response to different chemical stimuli. Two main hypotheses have been proposed: 1) lymphatic capillaries sprout from existing interrupted ones at the edge of the wound in analogy to the blood angiogenesis case; 2) lymphatic endothelial cells first pool in the wound region following the lymph flow and then, once sufficiently populated, start to form a network. Here we present two PDE models describing lymphangiogenesis according to these two different hypotheses. Further, we include the effect of advection due to interstitial flow and lymph flow coming from open capillaries. The variables represent different cell densities and growth factor concentrations, and where possible the parameters are estimated from biological data. The models are then solved numerically and the results are compared with the available biological literature.
Recommendations
- A mathematical model for lymphangiogenesis in normal and diabetic wounds
- A model of wound-healing angiogenesis in soft tissue
- A review of mathematical models for the formation of vascular networks
- scientific article; zbMATH DE number 1114141
- Modeling the role of angiogenesis in epidermal wound healing
Cites work
- In vitroVasculogenesis Models Revisited - Measurement of VEGF Diffusion in Matrigel
- A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics
- A mathematical model for lymphangiogenesis in normal and diabetic wounds
- A model for interstitial drainage through a sliding lymphatic valve
- A review of mathematical models for the formation of vascular networks
- ANALYSIS OF A MATHEMATICAL MODEL OF TUMOR LYMPHANGIOGENESIS
- Explicit solutions of a simplified model of capillary sprout growth during tumour angiogenesis
- scientific article; zbMATH DE number 4106424 (Why is no real title available?)
- Macrophage dynamics in diabetic wound dealing
- Mathematical modeling of capillary formation and development in tumor angiogenesis: penetration into the stroma
- Mathematical modeling of tumor-induced angiogenesis
- Mathematical Modelling of Angiogenesis in Wound Healing: Comparison of Theory and Experiment
- Mathematical modelling of flow in 2D and 3D vascular networks: Applications to anti-angio\-genic and chemotherapeutic drug strategies
- Modeling the role of TGF-\(\beta\) in regulation of the Th17 phenotype in the LPS-driven immune system
- Network development in biological gels: role in lymphatic vessel development
- Point Dynamics in a Singular Limit of the Keller--Segel Model 1: Motion of the Concentration Regions
- Point Dynamics in a Singular Limit of the Keller--Segel Model 2: Formation of the Concentration Regions
- Spatial patterning of the spruce budworm
- Wound healing angiogenesis: the clinical implications of a simple mathematical model
Cited in
(26)- Finite-time blow-up in low-dimensional Keller-Segel systems with logistic-type superlinear degradation
- Modelling skin wound healing angiogenesis: a review
- Wound healing angiogenesis: the clinical implications of a simple mathematical model
- A model of wound-healing angiogenesis in soft tissue
- Investigating a simple model of cutaneous wound healing angiogenesis
- Suppressing blow-up by gradient-dependent flux limitation in a planar Keller-Segel-Navier-Stokes system
- Global classical solutions in a self-consistent chemotaxis-fluid system with gradient-dependent flux limitation
- On an elliptic chemotaxis system with flux limitation and subcritical signal production
- Influence of flux limitation on large time behavior in a three-dimensional chemotaxis-Stokes system modeling coral fertilization
- Network development in biological gels: role in lymphatic vessel development
- Using experimental data and information criteria to guide model selection for reaction-diffusion problems in mathematical biology
- Radially symmetric solutions for a Keller-Segel system with flux limitation and nonlinear diffusion
- Modelling lymph flow in the lymphatic system: from 0D to 1D spatial resolution
- Blow up of solutions for a Parabolic-Elliptic chemotaxis system with gradient dependent chemotactic coefficient
- A critical blow-up exponent for flux limiation in a Keller-Segel system
- Global boundedness in a 2D chemotaxis-Navier–Stokes system with flux limitation and nonlinear production
- A unifying approach toward boundedness in Keller–Segel type cross‐diffusion systems via conditional L∞$L^\infty$ estimates for taxis gradients
- Global bounded solution to a forager-exploiter model with gradient dependent chemotactic coefficients
- On the existence of solutions for a parabolic‐elliptic chemotaxis model with flux limitation and logistic source
- Boundedness for the chemotaxis system in a flux limitation with indirect signal production
- Structure-preserving semi-convex-splitting numerical scheme for a Cahn-Hilliard cross-diffusion system in lymphangiogenesis
- Global existence and boundedness in a self-consistent chemotaxis-fluid system with flux limitation
- A structure-preserving quasi-convex-splitting finite-element scheme for a Cahn-Hilliard cross-diffusion system in lymphangiogenesis
- Self-similar solutions to a flux-limited Keller-Segel system
- Boundedness and finite-time blow-up for the chemotaxis system with indirect signal production and flux limitation
- A mathematical model for lymphangiogenesis in normal and diabetic wounds
This page was built for publication: Spatio-temporal models of lymphangiogenesis in wound healing
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q347055)
