An assessment of up- and down designs and associated estimators in phase I trials

zbMATH Open1341.62313MaRDI QIDQ3498063FDOQ3498063

Authors: K. T. Ng, S. G. Mohanty, Narayanaswamy Balakrishnan 

Publication date: 28 May 2008

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• scientific article; zbMATH DE number 590042

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Factorial statistical designs (62K15)

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• A new look at evaluating MTD designs in cancer research
• Derivation of Exact Distributions Following an Up-and-Down Design
• Dose finding using the biased coin up-and-down design and isotonic regression
• Title not available (Why is that?)
• Up-and-down designs for dose-finding
• Design and Analysis of Phase I Clinical Trials
• Comparison of response rate estimators of anti-cancer drugs in two-stage designs
• A method based on isotonic regression estimation for identifying the maximum tolerated dose

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